Pre_GI Gene

Host: NC_014256:485969 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014256:485969 Helicobacter pylori B8 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
485969486682714hypothetical proteinBLASTP
486679487173495hypothetical proteinBLASTP
487265487378114hypothetical protein
488306488938633hypothetical proteinBLASTP
4889804902001221putative transposaseQuickGO ontologyBLASTP
4907314921731443hypothetical proteinBLASTP
492700492828129hypothetical proteinBLASTP
4933274943941068hypothetical proteinBLASTP
494711495514804hypothetical proteinBLASTP
495486495737252hypothetical proteinBLASTP
495875496555681hypothetical proteinBLASTP
4967764977891014hypothetical proteinBLASTP
4977944990561263hypothetical proteinBLASTP
4990685003241257type IV secretion system protein TrbLQuickGO ontologyBLASTP
5003215017541434hypothetical proteinBLASTP
5017645037912028hypothetical proteinBLASTP
5037915048431053hypothetical proteinBLASTP
504844505008165hypothetical proteinBLASTP
505645506313669hypothetical proteinBLASTP
506360506737378hypothetical proteinBLASTP
506715507380666hypothetical proteinBLASTP
507454508257804hypothetical proteinBLASTP
508227508697471hypothetical proteinBLASTP
5087525108122061DNA topoisomerase IQuickGO ontologyBLASTP
5108335129622130type IV secretion system protein VirD4QuickGO ontologyBLASTP
512959513477519hypothetical proteinBLASTP
513474514418945type IV secretion system protein VirB11QuickGO ontologyBLASTP
514423514698276hypothetical proteinBLASTP
514715515677963hypothetical proteinBLASTP
5156905179302241hypothetical proteinBLASTP
5179145191221209type IV secretion system protein VirB10QuickGO ontologyBLASTP
5191195207741656type IV secretion system protein VirB9QuickGO ontologyBLASTP
5207715219071137putative VirB8 proteinQuickGO ontologyBLASTP
521928522044117hypothetical protein
5220375246132577type IV secretion system protein VirB4QuickGO ontologyBLASTP
524613524849237hypothetical proteinBLASTP
524861525124264hypothetical proteinBLASTP
525136525420285hypothetical proteinBLASTP
525398525775378hypothetical proteinBLASTP
525768525998231hypothetical proteinBLASTP
526001526789789hypothetical proteinBLASTP
526917527504588hypothetical proteinBLASTP
5275845286571074XerCD family integraserecombinaseQuickGO ontologyBLASTP
52869152878999hypothetical protein
529230529919690hypothetical proteinBLASTP
530373530486114hypothetical protein
530428530547120hypothetical proteinBLASTP
530818531642825MscS family small conductance mechanosensitive ion channelQuickGO ontologyBLASTP
531695531826132hypothetical proteinBLASTP
532010532567558hypothetical protein
532657533220564hypothetical proteinBLASTP
533224533328105hypothetical protein
5335435347001158cell division protein FtsZQuickGO ontologyBLASTP